Our goal is to better understand protein tyrosine phosphatases and develop novel therapeutics.

Our Research

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Our scientists come from diverse backgrounds, providing our lab with the knowledge required to achieve our goal of treating PTP implicated diseases. Come join us in our pursuit!

Our Team

Recent Publications

Read more about what we do.

Discovery of a selective TC-PTP degrader for cancer immunotherapy

Discovery of a SHP2 degrader with in vivo anti-tumor activity

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitinligase CBL at tyrosine371

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors

An Integrated Proteomic Strategy to Identify SHP2 Substrates

Cryo-electron microscopy structures of VCP/p97reveal a new mechanism of oligomerizationregulation

Functional interrogation and therapeutic targeting of protein tyrosine phosphatases

Systemic inhibition of PTPN22 augments anticancer immunity

SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer

Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis

Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids

Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases

Our goal is to better understand protein tyrosine phosphatases and develop novel therapeutics.

Work with us

Recent Publications