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Our scientists come from diverse backgrounds, providing our lab with the knowledge required to achieve our goal of treating PTP implicated diseases. Come join us in our pursuit! https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1767974818207-8CVU3GOM7TCHG6KTFK8B/anie70978-gra-0001-m.webp Home - Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1767974849928-CD5R4ZK2UEY8S7L2V32E/jm4c02580_0017.webp Home - Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1767974829493-QR8GPG2BK69Y5ZTWFJS8/Screenshot+2026-01-09+110548.jpg Home - The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1717698374868-2RZLJCF3YPZNPLVFFGWY/Yiming+offtarget.jpg Home - Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their anti-tumor activity in RAS-driven cancers https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1717698326297-3W61IYOQ5GV25Z0Y2PM8/Jiajun+JMC.jpeg Home - Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1717698227761-564D72M98FB8W2W77OGL/PRL2+Fred.png Home - Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1701814709104-9RP2PCT370AIC7K41VDU/TOC+graphic.jpg Home - Discovery of a selective TC-PTP degrader for cancer immunotherapy https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1701191770911-TKX9B2H8KF6R3LYTAM8S/PC-9.jpg Home - Discovery of a SHP2 degrader with in vivo anti-tumor activity https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1682783445837-MWXF38UEED7H61ZEF7KA/20230429115026.png Home - Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1682955314484-08JJGKU1OX1LT9SKAO1I/20230501113432.png Home - PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitinligase CBL at tyrosine371 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1682784041533-6CW3XSU66IFVONIJS3F0/images_large_jm2c01143_0020.jpeg Home - Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1682784041408-HRMFR8PT5PJJP869BBK6/images_large_pr2c00481_0006.jpeg Home - An Integrated Proteomic Strategy to Identify SHP2 Substrates https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1641329649417-0349KXZJSKFO1N0LJUIZ/Screen+Shot+2022-01-04+at+15.54.00.png Home - Cryo-electron microscopy structures of VCP/p97reveal a new mechanism of oligomerizationregulation Cryo-electron microscopy structures of VCP/p97reveal a new mechanism of oligomerizationregulation https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1629983994229-MSFPS19GVVSC6LVCA97M/BST_2021.png Home - Functional interrogation and therapeutic targeting of protein tyrosine phosphatases Functional interrogation and therapeutic targeting of protein tyrosine phosphatases https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628196399505-LVI2BZ7W2EKFUTJJ6N81/JCI_2020.png Home - Systemic inhibition of PTPN22 augments anticancer immunity Systemic inhibition of PTPN22 augments anticancer immunity https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628196865733-VJOYPU2362FCOYQUBV2M/Oncogene_2020.png Home - SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628196984989-3N3WXUMGFXDKO3I3T24G/JMC_2020.gif Home - Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628197239121-XQQBYFIB45P6YR0EIH51/PNAS_2020.png Home - Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628197558811-RF8C67SVDKUP9OCPYFJX/JBC_2020.png Home - Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628197822422-4XHB5AJR01FQERHAYM1N/JACS_2020_Dai.gif Home - Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628197875860-BYG5K2PCX7T2CPXCZGQN/ACS_Chem_Rev.gif Home - Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases https://www.zyzhanglab.com/opportunities daily 0.75 2024-09-24 https://www.zyzhanglab.com/publications daily 0.75 2026-04-01 https://www.zyzhanglab.com/zhong-yin-zhang daily 0.75 2021-08-27 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1630076543437-KJ00HOQRFP8KRZUZFAUT/ZHANG_4x5.jpg Zhong-Yin Zhang https://www.zyzhanglab.com/team daily 0.75 2026-01-09 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628194261706-UETQ1LE9B0W9IH3YSKQF/LabOutting+%2827+of+47%29.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1661971876008-PQH8H6ALC1LOXOAWPWB6/CDEE8E3E-A039-4206-B551-C44B226C138A.jpeg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628174890955-RVLGTLEJMONVADLGZXV0/LabOutting+%2826+of+47%29.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/699c4f6e-1055-4e61-b981-9f523425e388/Ayo_sm.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/14d09125-61c4-44eb-9e2e-7fd73d385bce/Screen-Shot-2023-10-23-at-9.17.39-AM.png Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/9a24ada0-eee6-4a92-b378-3cfebdfcb30d/Lab+page+photo.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/99011639-f46c-46b7-bf6b-144358b71564/gao811.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/ef7c8afc-1ba0-4216-94a5-67612acd0293/1734668697504.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/599418fc-90f9-4822-8e3c-4cdb686247ef/RayLai.png Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/5cbb7303-d084-4801-bf67-3d10ca872cfa/Jianping.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1e3ecd4b-dbd4-4b7b-b1f6-7aa28591af13/Haoran.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/e1c3c37c-974b-4ea0-97ab-992818df1245/pbhattar.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/f2c2de35-bd02-4c61-a5af-a77d94997720/Jinhong+Chen.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/e7ba1f3b-5927-4dd6-a175-116aefabe21f/Ahmed-Abou-Shanab-3.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/edc0a84a-7ebb-46ad-9f92-27caf8497ef8/Hossam+Saadawy.jpg Team https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/c1ff9765-b8f8-4a55-8749-96617e7239d8/Ashley+Chen.jpg Team https://www.zyzhanglab.com/research daily 0.75 2021-08-26 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/b4580db1-780b-4344-8d49-fce9fc34d1d7/Website+Images.jpg Research Chemistry-based approaches to drugging PTPs https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/5677683f-455a-4127-a0fa-d55ee90d59d4/Website+Images_2.jpg Research Our roles in the drug discovery pipeline https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/8fdd9ab8-34af-4eae-8f53-f1fc23dc584c/Biology.jpg Research Our lab is working to fully elucidate the role of PRL2 in disease state pathogenesis. https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628194304573-U6LNHVWM4T0CHRHZJ70E/IMG_8895.jpg Research - Chemistry Our chemistry lab space is located in the drug discovery facility (DRUG 218) and is outfitted with state-of-the art equipment including: 8 fume hoods, 4 flash purification systems, 4 rotary evaporators, a CLARIOstar plus plate reader, an AKTA plus FPLC, a preparatory HPLC, a Lyophilizer, and an analytical LC-MS/MS. https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628194258053-NCILFVMG5Z935A1PYEKA/IMG_8902.jpg Research - Biology Our Biology lab space is located in the Hansen life sciences building (HANS). Here we are fully outfitted to perform biology experiments, with access to: a Milli-Q® water purification system, Azure Biosystems gel camera, Sorvall ultra centrifuge, Countess II FL automatic cell counter, NIKON Eclipse fluorescence microscope, 2 cell culture hoods, 4 cell culture incubators, 2 incubator shakers, 3 PCR machines, a NanoDrop Spectrophotometer, a sonicator, Microtome tissue sectioning device, and a SpectraMax plate reader. https://www.zyzhanglab.com/research-1 daily 0.75 2026-04-01 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1630700969280-DFZDY9OKXI31U3NJ09QN/unsplash-image-As8b7TbeshI.jpg Research https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1630701284355-40ZSEWAY0ZQSRWKIJZ6G/unsplash-image-lwbNXxRc_c8.jpg Research https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1630701490300-MJ78W6ZGZNXCOS6QGJFO/unsplash-image-KZaJ8SLzsmw.jpg Research https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/b4580db1-780b-4344-8d49-fce9fc34d1d7/Website+Images.jpg Research Chemistry-based approaches to drugging PTPs https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/5677683f-455a-4127-a0fa-d55ee90d59d4/Website+Images_2.jpg Research Our roles in the drug discovery pipeline https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/8fdd9ab8-34af-4eae-8f53-f1fc23dc584c/Biology.jpg Research Our lab is working to fully elucidate the role of PRL2 in disease state pathogenesis. https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628194304573-U6LNHVWM4T0CHRHZJ70E/IMG_8895.jpg https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1628194258053-NCILFVMG5Z935A1PYEKA/IMG_8902.jpg https://www.zyzhanglab.com/drug-discovery daily 0.75 2026-03-13 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767720671-4KRAUEJB0FU2GY3C2YMM/tempImageuOVqFH.gif Drug Discovery https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767751343-ACKHN850Q2QMOEUM9LHS/tempImageH6c09f.gif Drug Discovery https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767776807-2J7OW2OHDWL5N17XRNJF/IMG_1838.jpeg Drug Discovery https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767807913-UM3XWTSZG9ER4VXLI19F/IMG_1855.jpeg Drug Discovery https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767833793-RI123YLV2EII3UNU28EF/IMG_1847.jpeg Drug Discovery https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767890790-P2SQIJS3K3ZLKYZ3MPBM/IMG_1845.jpeg Drug Discovery https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660767936085-SJ03VX9NDVRERV5W04GV/IMG_1844.jpeg Drug Discovery https://www.zyzhanglab.com/hansen-life-sciences-1 daily 0.75 2022-08-31 https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660768102787-GZ4W7JZKOQOM7JAN8AMU/IMG_1830.jpeg Hansen Life Sciences https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1660768143873-1JJK9H4OL8DS7955KO16/IMG_1835.jpeg Hansen Life Sciences https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1661972063735-PR4P45NMBUFJUWN794ZV/25D30E60-FD1C-496C-874F-F2A3C0AF0FC4.jpeg Hansen Life Sciences https://images.squarespace-cdn.com/content/v1/60ba905f267cf41b39a60f0f/1661972113770-LYT4QT1E85N8QISJ8NE7/D2F0EB82-9C8B-4175-96DF-B279852C6CB8.jpeg Hansen Life Sciences